Publishing a Microsoft ClickOnce Setup / Deploying ClickOnce using an Apache Webserver
Although it might seem as though you can only use Microsoft’s ClickOnce installers with IIS, this is simply not true, as all you need to do is set some mime types on the server.
The simplest way to do this is to add the following lines to a .htaccess file in the folder containing the ClickOnce files:
AddType application/x-ms-application application
AddType application/x-ms-manifest manifest
AddType application/octet-stream deploy
For some reason I also needed the following line in my .htaccess file
AddType application/x-msdownload dll
Once you’ve done this, your ClickOnce applications should install correctly. Since the release of Microsoft .NET Framework 3.5 SP1, ClickOnce applications work in both Internet Explorer and Mozilla Firefox. Earlier versions of the Framework will only run ClickOnce applications from Internet Explorer.
You may also want to add the correct mime types for XPS files, XAML files, XAML Browser Applications (XBAPs), and Silverlight 2.0 Applications. To add these, simply add the following lines:
AddType application/vnd.ms-xpsdocument xps
AddType application/xaml+xml xaml
AddType application/x-ms-xbap xbap
AddType application/x-silverlight-app xap
more information on AddType Directive
Important: Use FTP when publishing from Visual Studio, Unless you want to install FrontPage Server Extensions on your Apache!
Using a ClickOnce application with FireFox
Currently ClickOnce applications will only work with Internet Explorer, you use FireFox, but you will need to install the FFClickOnce extension.